The fact that CA areas of the hippocampus and dorsomedial striatal areas are connected and involved in flexible spatial learning (Devan et al., 2011; Fouquet et al., 2013; Delcasso et al., 2014), combined with the observed effects on spatial/contextual learning of MD, their reversal by MIF treatment and the c-Fos immunoreactivity data, prompted us to study changes in excitability in these areas. Here, MIF is linked to Menkes disease.