Since ENG plays an important role in the angiogenesis, in this review, we summarize the influences of ENG on endothelial function and the angiogenesis, as well as how ENG-deficiency contributes to the pathogenesis of cerebrovascular diseases, including ischemic stroke and intra-cranial hemorrhage, as well as cerebrovascular malformation, stenosis and occlusion. This evidence concerns the gene ENG and ischemic stroke.