CYP1A1 and glioma: In this study, therefore, using transgenic Cyp double (Cyp1a1/1a2) or triple (Cyp1a1/1a2/1b1) KO mice, in vivo and C6 glioma cell culture in vitro, we investigated the effects of β-naphthoflavone (BNF), a known inducer of CYP1A1/1A2 and an AHR agonist, whose metabolic products, unlike other PAHs like BaP, are neither reactive nor toxic.