Out of 358 cases of serological proven dengue, this study examined only 30 cases (N = 30, males = 17 and females = 13 with a mean age of 39.86 ± 12.95) of confirmed dengue fever which was proved clinically as well as serologically by dengue IgM reactivity beyond 7th day of febrile illness (all these 30 patients tested negative for NS1 antigen). The gene discussed is CD40LG; the disease is dengue disease.