Furthermore, Xie et al. reported that mAdSCs induced M2 macrophages and the T-reg phenotype in a manner dependent on the number of cells in vitro and also increased T-reg and M2 macrophages and decreased the accumulation of CD4 + CD28− and CD8 + CD28− T cells and Ly6G/C+ neutrophils in lesions in a mouse model of abdominal aortic aneurysm prepared with B6 mice37. Here, CD28 is linked to abdominal aortic aneurysm.