Transactive response DNA binding protein of 43 kDa (TDP-43) is an RNA binding protein linked to the pathophysiology of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (for review, see Renton et al. 20141). The gene discussed is TARDBP; the disease is neurodegenerative disease.