These include pyruvate phosphoglycerate kinase 1 (PGK-1) and hexokinase II (HKII), involved in the glycolytic pathway29–32, and c-Met and VEGF, receptor tyrosine kinase drivers of the stem cell phenotype and neoangiogenesis in glioblastomas, respectively11,16,33. This evidence concerns the gene HK2 and glioblastoma.