Guanylate cyclase activator 2 A (GUCA2A) and guanylate cyclase activator 2B (GUCA2B) are related to ion and fluid homeostasis, irritable bowel syndrome (IBS), abdominal pain31,32, growth, and intestinal barrier integrity33, and were expressed in the gastrointestinal tract34. The gene discussed is GUCA2B; the disease is irritable bowel syndrome.