Guanylate cyclase activator 2 A (GUCA2A) and guanylate cyclase activator 2B (GUCA2B) are related to ion and fluid homeostasis, irritable bowel syndrome (IBS), abdominal pain31,32, growth, and intestinal barrier integrity33, and were expressed in the gastrointestinal tract34. This evidence concerns the gene GUCA2A and irritable bowel syndrome.