It is worth mentioning that FGFR2 is involved not only in the embryonic development of the metanephric urinary tract but also in that of the skeleton and skin, and mutations in the gene in humans can cause Crouzon syndrome, Pfeiffer syndrome, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, or Saethre-Chotzen syndrome. This evidence concerns the gene FGFR2 and Apert syndrome.