PTPN6 and renal fibrosis: Figure 3 shows significant associations for hypermethylation at cg19942083 with lower renal fibrosis (P = 1e-07, Fig. 3a), higher eGFR (P = 6.4e-06, Fig. 3b), and lower PTPN6 expression (P = 3.2e-3, Fig. 3c), suggesting lower renal PTPN6 expression is associated with a more favorable kidney function profile.