Genome-wide and homozygosity mapping studies in patients with autism have uncovered copy number variations in the ubiquitin ligases PARK2, RFWD2, and FBXO4011–13, a homozygous missense mutation in the HECT domain protein HERC214, and a deletion in the regulatory region of the gene encoding the RING finger ubiquitin ligase RNF815. Here, PRKN is linked to autism.