Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) aggregates in various conformations (Glenner and Wong, 1984; Masters et al., 1985; Dickson, 1997; Selkoe, 2001), the occurrence of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau proteins (Grundke-Iqbal et al., 1986; Kosik et al., 1988; Goedert et al., 1992), and synaptic dysfunction (Masliah et al., 1989; Mufson et al., 2000). Here, MAPT is linked to Alzheimer disease.