A novel study showed that nuclear factor (erythroid-derived 2)-like 2 (Nrf2) siRNA could effectively interfere with Nrf2 expression in BMSCs and reduce the repair ability of exogenous BMSCs in MI heart, which increased collagen deposition in the infarcted area, thus contributing to ventricular remodeling and reducing cardiac function in a rat model [37]. The gene discussed is NFE2L2; the disease is myocardial infarction.