We characterized the cohort’s CSF amyloid (β-amyloid 1–40 and 1–42 [Aβ40 and Aβ42, respectively]), tau (total tau and tau phosphorylated at threonine 181 [t-tau and p-tau181, respectively]), neurodegenerative (neurofilament light chain [NfL]), and candidate endothelial markers (soluble vascular cell adhesion molecule 1 [sVCAM-1]; soluble intercellular cell adhesion molecule 1 [sICAM-1]) [16, 17] to test their associations with cognitive impairment within each race. This evidence concerns the gene NEFL and Cognitive impairment.