We found that silencing WDR7-7 with specific shRNAs increased GPR30 levels in both ER+ (MCF-7, T47D) and ER− breast cancer cells (SKBR3, MDA-MB-468), contributing to the promotion of cell growth (p < 0.05; Fig. 4a-b, g-h). Here, ESR1 is linked to breast carcinoma.