Cir-ITCH competitively bound to tumor-associated miRNAs (miR-7, miR-17, and miR-214) to up-regulate the expression of ITCH, promoting the ubiquitination and degradation of phosphorylated Dvl2, and thereby inhibiting the activation of Wnt/β-catenin pathway [65]. Here, DVL2 is linked to neoplasm.