Interestingly, energy metabolism of breast cancer cells can be affected by sodium butyrate however sodium butyrate manipulates metabolic pathways differently through attenuation of glycolysis and glucose 6-phosphate dehydrogenase activity in MCF-7 and activation of glucose 6-phosphate dehydrogenase and consumption of oxygen in MDA-MB-231 [23]. This evidence concerns the gene G6PD and breast cancer.