LRP4 and Cenani-Lenz syndrome: Pathogenic missense or splicing LRP4 variants are a known cause of Cenani‐Lenz syndrome, which is characterized by a less severe phenotype than was seen in our patient, of syndactyly/oligodactyly and kidney abnormalities.24 A recent report of truncating variants causing a severe lethal prenatal form28, 29 is consistent with Cenani‐Lenz syndrome being the result of hypomorphic variants.