In this study, hepatic transcripts of Acox and Cyp4a10, two PPARα target genes were increased in CF-mothers and their fetuses at day 18 of pregnancy, then returned to basal levels (similar to their postnatal C counterparts), consistent with the duration of CF administration and the ability of CF to cross placenta [27]. The gene discussed is ACOX1; the disease is cystic fibrosis.