ADRB3 and cystic fibrosis: In addition to cell autonomy, the role of external factors such as sympathetic innervation on this differential response between groups in WAT thermogenesis was unclear, though the mRNA levels of Adrb3 and protein amount of TH, widely considered a marker of noradrenergic nerve fibers [45], were not increased in CF-offspring across 3 fat depots at P84.