The mean change in serum HMGB1 levels after 96 weeks of therapy was -0.4 ± 2.6 ng/mL in those with NASH resolution compared to 0.7 ± 1.8 ng/mL in those without (P = 0.15) (S5 Table). The gene discussed is HMGB1; the disease is metabolic dysfunction-associated steatohepatitis.