HMGB1 and metabolic dysfunction-associated steatohepatitis: The mean change in the serum HMGB1 levels at week 96 irrespective of treament assignment was not statistically significantly different (-0.5 ± 1.5 vs. -0.5 ± 2.5 ng/mL, P = 0.22) (S2 Table) between the patients who did and did not achieve histological improvement and with or without resolution of NASH (No NASH resolution vs. NASH resolution: -0.6 ± 2.5 vs. -0.1 ± 2.2 ng/mL, P = 0.57) (S3 Table).