Isolated long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD, OMIM#609016) is an autosomal recessive disorders associated with mutations of the HADHA gene first described in 1989 by Wanders et al.[10]. The gene discussed is HADHA; the disease is long chain 3-hydroxyacyl-CoA dehydrogenase deficiency.