Our data, which demonstrate that impaired endothelium-dependent vasodilation in T2D mouse coronary arterioles was restored using IL-6 neutralization strategy (Fig 1A and 1B), provides direct evidence of the key role played by IL-6 in diabetes-induced impairment of ACh- and the physiologically relevant, flow-mediated vasodilation. The gene discussed is IL6; the disease is type 2 diabetes mellitus.