Moreover, these findings clearly indicate that down-regulation of Sirt1 by mRNA interference abrogates the suppressive effects of resveratrol on TNF-β- and NF-κB signaling, highlighting the important role and function of Sirt1 for anti-inflammatory and anti-cytokine pathway of resveratrol in RA/OA inflammatory joint environment. This evidence concerns the gene LTA and rheumatoid arthritis.