These results show clearly that TNF-β-mediated NF-κB activation in chondrocytes is similar to Sirt1-ASO or NAM, indicating that Sirt1 is one of the main downstream signaling molecules for TNF-β-signaling that may be modulated by resveratrol-mediated signaling pathways in RA inflammatory microenvironment. This evidence concerns the gene SIRT1 and rheumatoid arthritis.