TRAF3 and Miyoshi myopathy: A previous study explained that the BAFF promoter was an essential activation element of nuclear factor kappa B (NF-κB) transcription triggered by the adhesion of MM cells to BMSCs.26 NF-κB2 activation relies on both NIK (NF-κB-inducing kinase) and its downstream kinase IKKα with the persistent degradation of TRAF3 and increased expression of NIK.