MΦs were cultured alone or co-cultured with MM cell lines for 24 h, the suspended MM cells were removed and washed with phosphate-buffered saline (PBS) to obtain pure MΦs, we found MΦs in co-cultured condition led to an increased expression of BAFF as detected by western blot (Figure 5a). The gene discussed is TNFSF13B; the disease is Miyoshi myopathy.