STAT3 and biliary atresia: In a mouse model of biliary atresias, IL-17 A was highly produced by γδ cells in the liver, thereby inducing inflammation and destruction of the biliary system.48 In a study of Meng et al.,49 mouse models and cell lines were used to demonstrate that IL-17 A could activate Küpffer cells and stellate cells through the activation of Stat3 signalling and as such induce fibrosis and inflammation in the diseased liver.