In addition, a novel method combined anti-AFP-coated magnetic Fe3O4 nanoparticles with low-frequency electromagnetic field exposure induced the apoptosis of Bel-7402 and HepG2 hepatoma cells lines without manifesting any significant side effects on HL-7702, a normal hepatic cell line.18 Notably, EGCG could inhibit AFP secretion in human hepatoma-derived PLC/PRF/5 cells19 and reduces the serum AFP level in HCC rat models.20 However, the mechanism underlying the way by which EGCG regulates AFP levels in HCC cells remains elusive. The gene discussed is AFP; the disease is hepatocellular carcinoma.