POMC and hypophysitis: The order of hormone deficiency specific to hypophysitis is as follows: ACTH > TSH > luteinizing hormone/follicle-stimulating hormone > prolactin > growth hormone.[11] Until now, all reported cases of nivolumab-induced hypophysitis were focused on isolated ACTH deficiency.[8,12–15] It is likely that corticotrophin cells are more vulnerable to nivolumab induced autoimmune activation.