In a study of esophageal cancer cell, miR-146b acted as a tumor suppressor by targeting CCAAT/enhancer-binding proteins β liver-enriched transcriptional activator protein 2 (C/EBPβ LAP2) to inducing cell proliferation and repressing cell apoptosis.[36] In addition, miR-146b expression was associated with the TNM stage, liver metastasis and differentiated degree, and its overexpression showed better OS in patients with gallbladder cancer (GBC).[35] These studies illustrates that miR-146b serves as tumor suppressor on the prognosis of carcinomas. This evidence concerns the gene CEBPB and gallbladder cancer.