Targeting Wnt- CTNNB-1 signaling by natural compounds is not only limited to colon cancer: the antitumor activity of the mushroom component against human meningioma cells has also been reported.68 Ganoderic acid A and ganoderic Acid DM suppress the expression of Wnt 5α/β and β-catenin and also cause the phosphorylation of GSK3β, which results in the proteaosomal degradation of β-catenin in the cytoplasm. The gene discussed is CTNNB1; the disease is malignant colon neoplasm.