One of the recent studies demonstrated the effect of antroquinonol (ANQ) on cancer stem cell-like properties in colon cancer.42 The authors demonstrated the interaction of ANQ with PI3K, identified by molecular docking, and further showed the suppression of PI3K/AKT/β-catenin signaling in colon cancer, which is crucial for regulating the expression of pluripotent genes. This evidence concerns the gene PIK3CA and malignant colon neoplasm.