From the evidence presented in this review, we can anticipate the molecular mechanism of different mushroom originated compounds, where they exhibit anticancer potential through modulating different nodes of PI3K/Akt, Wnt-CTNNB1, and NF-κB signaling pathways and thus affecting a variety of cellular processes, for example, by induction of apoptosis, cell cycle arrest, increasing the antioxidant capacity of host, and interfering with tumor angiogenesis. This evidence concerns the gene PIK3CA and neoplasm.