AKT1 and cancer: In harmony with this study, the antiproliferative activity of proteoglycan (P1) from Phellinus linteus was demonstrated in multiple human cancer cells and in BALB/c-nu/nu mice bearing HT-29 cells.57 As far as the molecular mechanism is concerned, P1 resulted in a notable decrease in AKT, Reg IV, EGFR, and plasmatic PGE2 concentrations measured by ELISA.