TCF7L2 and Familial adenomatous polyposis: APC, CTNNB1, AXIN1, FAM123B, and TCF7L2 are the key nodes of Wnt signaling that harbor somatic mutations associated with some of the common human cancers.64 The development and progression of sporadic colorectal cancer (CRC) and familial adenomatous polyposis (FAP)-associated disease are believed to be because of the mutations in APC (adenomatous polyposis coli) gene.65 In addition to this, two inactivating mutations often occur in the APC gene, one leading to allelic loss and other resulting in a truncated protein.66,67