Furthermore, expression of ASS1, AMPK‐α1, or RNF44 represented as H‐score confirmed that BR/BMR tumor samples had 2‐7‐fold lower ASS1 and AMPK‐α1 than the average levels but fivefold higher RNF44 compared to naïve melanoma samples (Fig. 7D). This evidence concerns the gene RNF44 and neoplasm.