CREB1 and Alzheimer disease: Present data suggest that, at least, monomers and oligomers exert distinct effects on CREB protein functions, and that a loss of functional monomers and a building‐up of toxic oligomers could operate coordinately in determining the CREB dysregulation observed in AD (Pugazhenthi et al., 2011; Bartolotti et al., 2016a,b).