Accordingly, CREB activation is impaired in the brain of patients with AD and Tg2576 mice (Pugazhenthi et al., 2011; Bartolotti et al., 2016a,b), where it is associated with decreased levels of CREB‐regulated BDNF release (Pugazhenthi et al., 2011). Here, BDNF is linked to Alzheimer disease.