Furthermore, after LDDST, the 24 h UFC (Post-L-Dex)/(Pre-L-Dex) in the PPNAD group was significantly higher than that of the ADA group (1.29 vs. 0.78, P < 0.017), whereas the ratio between PPNAD and BMAH showed no difference (Fig. 1d). This evidence concerns the gene ADA and primary pigmented nodular adrenocortical disease.