Using the ratio method, the effect of a 1-unit increase in ln(sIL-6R) levels (used as a proxy for inhibition of IL-6 classic signaling) on ln(CRP) levels was −0.26 (95% CI, −0.32 to −0.21), and the effect of a 1-unit increase in ln(CRP) levels on the ln(OR) of schizophrenia was −0.14 (95% CI, −0.23 to −0.05). This evidence concerns the gene CRP and schizophrenia.