Interleukin-6 is known for its pivotal role in integrating immune response, such as by inducing hepatic acute-phase proteins, differentiation of T cells, and tissue regeneration.43 Apart from being a sensitive marker of systemic inflammation and tissue damage, CRP is an acute-phase protein that contributes to host defense against infection.44 C-reactive protein binds to phosphocholine expressed on the surface of cells and some bacteria, which activates the complement system, promoting phagocytosis and clearance of necrotic and apoptotic cells and bacteria.44,45. This evidence concerns the gene IL6 and infection.