CRP and schizophrenia: Regarding CRP, when the liberal set of 18 CRP-associated variants was used, results were consistent among the 3 MR methods, with ORs of schizophrenia of 0.90 (random effects 95% CI, 0.84-0.97), 0.91 (95% CI, 0.85-0.98), and 0.93 (random effects 95% CI, 0.82-1.05) per 2-fold increment in circulating CRP levels using IVW, weighted median, and MR Egger regression approaches, respectively (Figure).