CRP and schizophrenia: Moreover, part of the association between IL-6 signaling and schizophrenia might be mediated by CRP levels, which is consistent with previous knowledge on the major role of IL-6 in inducing acute-phase response and the fact that lower CRP levels are a downstream effect of inhibiting IL-6 classic signaling.26,41,42 For IL-1Ra, point estimates were inconsistent between instruments, and 95% CIs were large.