CRP and mental disorder: As an example, several types of infection (ie, HIV as well as hepatitis A, B, and C) appear to be more prevalent among individuals with mental disorders, including schizophrenia, in multiple settings.51 An MR study reported that genetic predisposition to higher CRP levels was not associated with increased infection risk in adults.50 To our knowledge, no existing MR study has investigated IL-6 and CRP effects on early life infection risk.