Most frequently found ACR criteria contributing to the diagnosis of SLE before pregnancy were arthritis, renal involvement, positive ANA, and hematological (leuco-, lymphocyto-, or thrombocytopenia, hemolytic anemia) and/or immunological (anti-dsDNA, anti-Smith, or anticardiolipin antibodies or LAC) anomalies. The gene discussed is LCT; the disease is arthritic joint disease.