Yasar et al. indicated that use of diuretics, angiotensin-1 receptor blockers, and angiotensin-converting enzyme inhibitors was independently associated with lower incidence of Alzheimer's disease in participants with normal cognition, while, in mild cognitive impairment patients, diuretic use significantly reduced the risk of Alzheimer's disease [18]. Here, ACE is linked to early-onset autosomal dominant Alzheimer disease.