Suggestive associations of symptoms of sleep apnea were observed with 11 rare variants (located in KANK2, LCN6, TRAF3, PLEK, HIF1A, SLC45A3, ERCC1/CD3EAP, MRGPRE, GRAMD4, TYW5, CST5) (Table 3). This evidence concerns the gene HIF1A and Sleep apnea.