Elevated expression of or mutations in HsMORC1, HsMORC2, and HsMORC4 are linked to breast cancer, multiple myeloma, carcinomas, or B cell lymphoma, while HsMORC3 and SMCHD1 (MORC5) are associated with tumor suppression (Table 6; Li et al., 2013). Here, SMCHD1 is linked to neoplasm.