Furthermore, the study also showed that IL-1β-induced MMP-1 and MMP-13 is partly mediated via RANTES/CCL5 and there exists an opportunity to therapeutically limit the role of RANTES/CCL5 in the process of tissue destruction in RA by reducing its interaction with HSPGs found on the cell surface and ECM, or inhibiting the signaling proteins such as PKCδ in RASFs. The gene discussed is CCL5; the disease is rheumatoid arthritis.