Lnk is a regulator of Jak2 signaling in myeloid cells (36–38), and the T1D risk SNP for SH2B3/Lnk is associated with altered expression of key elements of IFNγ signaling including signal transducer and activator of transcription 1 (STAT1) (39). The gene discussed is SH2B3; the disease is type 1 diabetes mellitus.