Another recently published meta-analysis concerning C-reactive protein (CRP) in different mood states (mania, depression, euthymia vs. healthy controls) in BSD patients found moderately increased CRP levels for BSD patients in euthymic and depressed states, substantially increased CRP levels during mania, and a reduction of CRP levels in BSD patients achieving euthymia after treatment (20). The gene discussed is CRP; the disease is depressive symptom measurement.