NFKB1 and bipolar disorder: The literature search was conducted using the MeSH terms “bipolar disorder,” “mood disorder,” “manic disorder,” “mania,” and the modifiers “youth,” “treatment,” “antipsychotics,” “inflammation,” “CRP,” “IL-6,” “NF-kB,” “steroids,” “cortisol,” “glucocorticoids,” “sex steroids,” “testosterone,” “androgens,” “estradiol,” “body composition,” “frailty,” “muscle mass,” or “fat mass,” The original PubMed search was conducted for references published between January 1, 1950 and February 15, 2017.