For example, two AAPs: estrogen receptor alpha (ER-alpha) and cyclooxygenase-2 (COX-2), play crucial role on the pathogenesis of several aging-associated diseases, such as Alzheimer's disease and osteoporosis (Kermath et al., 2014; Kim et al., 2016). The gene discussed is PTGS2; the disease is early-onset autosomal dominant Alzheimer disease.