Among RASopathies, craniosynostosis appears to be consistently associated with NS and CFC syndrome only, and with mutations limited to PTPN11, SHOC2, KRAS, and BRAF (Takenouchi et al., 2014; Addissie et al., 2015; Ueda et al., 2017). This evidence concerns the gene KRAS and cardiofaciocutaneous syndrome.