CFC syndrome is caused by mutations in BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase *164757) (about 70% of cases), MAP2K1 (Mitogen-activated protein kinase kinase, *176872) and KRAS (KRAS Proto-Oncogene, GTPase, *190070). Here, KRAS is linked to cardiofaciocutaneous syndrome.