NOTCH2 and hepatocellular carcinoma: Compared with non-HCC tissues in four studies15,19,21,23, Notch 2 was associated with a decreasing tendency in HCC tissue (OR = 0.60, 95%CI: 0.30 to 1.20; P = 0.237, I2 = 27.7%; Fig. 2B) with moderate quality evidence according to the GRADE assessment (Table 2).