Moreover, the greater possibility of a larger (>5 cm) tumor size (OR = 0.59, 95%CI: 0.41 to 0.85), positive tumor metastasis (OR = 0.42, 95%CI: 0.24 to 0.73) and positive microvascular invasion (OR = 0.53, 95%CI: 0.31 to 0.88) were linked with high Notch 1 expression in HCC. This evidence concerns the gene NOTCH1 and hepatocellular carcinoma.