JAG1 and hepatocellular carcinoma: Compared with non-HCC tissues from five studies14,15,19,20,23, the outcome of Jagged 1 (OR = 1.47, 95%CI: 0.23 to 9.53; P = 0.000, I2 = 96.7%; Fig. 2E) did not differ between the two groups, which displayed an increasing trend in HCC tissues.