NOTCH1 and hepatocellular carcinoma: We found that Notch 1, Notch 3, Notch 4 and Jagged 1 were associated with higher expression levels in HCC tissues compared with non-HCC tissues (both pericarcinomatous tissues and normal control; Fig. 2A,C–E), while Notch 2 was associated with lower expression levels (Fig. 2B).