KDR and portal hypertension: This KDR overexpression was efficiently and significantly reduced (by 75%, p = 0.0014) after systemic treatment with siRNAKDR-lipoplexes (four tail-vein injections on consecutive days, starting immediately after portal hypertension induction) (Fig. 5C), compared with mice treated with unrelated Luciferase siRNA lipoplexes (siRNALuc-lipoplexes) (Fig. 5D; full blots are shown in Supplementary Fig. S2C).