Moreover, some Apoptin-interacting molecules such as peptidyl-prolyl isomerase like 3 (Ppil3)38, huntingtin-interacting protein 1 (Hip1)39, anaphase-promoting complex 1 (APC1)40 or death effector domain-associated factor (DEDAF)41 identified in Apoptin-induced apoptotic cells might be examined while investigating the importance of VP2 in the regulation of apoptosis when Apoptin is introduced into cancer cells or in CAV-infected host cells. The gene discussed is RYBP; the disease is cancer.