The other gene examined in multiple longitudinal G-NI studies was NRG1, with results suggesting an effect for a 5’ SNP on LV changes in FEP patients and a 5’ microsatellite on the trajectory of brain changes in COS patients and controls.36,40 These two NRG1 studies and a COMT study were the only studies in this review to report that certain genetic variants were associated with greater progressive brain changes in patients but not in controls.36,40,41 These results suggest that certain genetic variants may have specific effects on progressive brain changes in psychosis. The gene discussed is NRG1; the disease is psychotic disorder.