For example, genetic variants in genes related to inflammation and oxidative stress processes (such as genes involved in the synthesis and metabolism of glutathione, manganese superoxide dismutase, interleukins, major histocompatibility complex [MHC], or complement components) have increasingly been implicated in the pathophysiology of schizophrenia and other psychotic disorders,58,59 but are yet to be explored in a longitudinal G-NI study. This evidence concerns the gene HLA-C and psychotic disorder.