Since the anti-tumoral immune activity to AOM/DSS-induced CRC tumors is mainly mediated by cytotoxic CD8+ T cells, whose function is controlled by regulatory FOXP3+ T cells (Tregs)40, we examined whether TREM-1 signaling negatively regulates the generation of Tregs in CRC lesions of Trem1+/+ mice. The gene discussed is FOXP3; the disease is infectious otitis media.