Rather we believe that analogous to the situation in the inflamed colonic mucosa where resident Ly6C− MHCII+ macrophages largely retain their hyporesponsive signature and remain TREM-1low/− 43,44, macrophages in colorectal tumors are also relatively inert to pro-inflammatory stimuli in their local environment, at least with respect to an upregulation of TREM-1. The gene discussed is TREM1; the disease is colorectal neoplasm.