MAPK14 and neoplasm: It is important to note that membership to a module that positively correlates with proximity to tumour may be indicative of either a function in early tumourigenesis (e.g. MAPK14) or a protective role in response to the increased stress and dysregulation of the cellular environment (as genes in these modules are enriched for somatic mutations in tumours with both gain-of-function and loss-of-function consequences).