Du et al reported that, in addition to MS, elevated levels of nontraditional risk factors and the visceral adiposity index scores in MHO individuals could contribute to the increased CVD risk observed in the long-term studies.12 In the present study, we found that, compared to metabolic healthy normal-weight individuals, the individuals with MHO phenotypes have a higher prevalence of low adiponectin and high leptin levels as well as a high L:A ratio, which play a role in increased risk of hypertension in MHO individuals. The gene discussed is LEP; the disease is myeloid sarcoma.