Seth et al reported that increased circulating leptin levels are common in obesity and are independently associated with CVD in humans.32 Previous studies have demonstrated that hypoadiponectinemia is a predictor for the development of hypertension and a risk factor for atherosclerosis.33,34 In this study, our results also revealed a significant relationship between the adipokines levels and SBP as well as DBP. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.