We made four important observations: 1) In human liver, Tetherin has a membrane distribution with a particular affinity to bile canalicular membrane (Fig 3D) in addition to the cytoplasmic localisation (Fig 3C) reported in literature [10]; 2) In human liver failure due to HEV, there is an overexpression of Tetherin in the HEV infected hepatocytes (Fig 3R–3T). Here, BST2 is linked to liver failure.